Pubblicazioni scientifiche

Unilateral multiple serous retinal detachments secondary to non-Hodgkin's lymphoma responsive to systemic steroids

European Journal of Ophthalmology 2021/9

Vujosevic S, Toma C, Muraca A, Alkabes M, Villani E, Nucci P, De Cilla S


To describe a case of unilateral multiple bullous neurosensory retina detachments (NRDs) secondary to non-Hodgkin's aggressive large B-cell lymphoma treated with chemotherapy and high doses of systemic steroids.


A case report based on patient observation, clinical records, and retinal imaging during 2 years of follow-up.


A 26-year-old Hispanic man presented at our clinic with sudden unilateral visual loss and multiple NRDs in the left eye with increased choroidal thickness, 1 week after oral steroid treatment due to low back pain and fever. In the following days, a non-Hodgkin's aggressive large B-cell lymphoma was diagnosed. The patient underwent three cycles of chemotherapy (CHT) with protocol R-CHOP21 (including oral prednisone) with complete resolution of NRD. During 2 years of follow-up, no recurrence of NRD occurred, despite the need to continue CHT with oral steroids for a year due to lymphoma relapse.


Neurosensory retina detachments may be an initial manifestation of large B-cell lymphoma as a consequence of a pro-inflammatory state involving the chorioretinal structures, thus adding steroid treatment could be useful for its resolution.



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